Advanced automatic mixing tools for music

PhDThis thesis presents research on several independent systems that when combined together can generate an automatic sound mix out of an unknown set of multi‐channel inputs. The research explores the possibility of reproducing the mixing decisions of a skilled audio engineer with minimal or no human interaction. The research is restricted to non‐time varying mixes for large room acoustics. This research has applications in dynamic sound music concerts, remote mixing, recording and postproduction as well as live mixing for interactive scenes. Currently, automated mixers are capable of saving a set of static mix scenes that can be loaded for later use, but they lack the ability to adapt to a different room or to a different set of inputs. In other words, they lack the ability to automatically make mixing decisions. The automatic mixer research depicted here distinguishes between the engineering mixing and the subjective mixing contributions. This research aims to automate the technical tasks related to audio mixing while freeing the audio engineer to perform the fine‐tuning involved in generating an aesthetically‐pleasing sound mix. Although the system mainly deals with the technical constraints involved in generating an audio mix, the developed system takes advantage of common practices performed by sound engineers whenever possible. The system also makes use of inter‐dependent channel information for controlling signal processing tasks while aiming to maintain system stability at all times. A working implementation of the system is described and subjective evaluation between a human mix and the automatic mix is used to measure the success of the automatic mixing tools

Circumnuclear structure and kinematics in the active galaxy NGC 6951

A study is presented of the central structure and kinematics of the galaxy NGC 6951, by means of broad band B'IJK images and high resolution high dispersion longslit spectroscopy, together with archival HST WFPC2 V and NICMOS2 J and H images. We find that there is evidence of two modes of star formation, in bursts and continuously. The equivalent width of the CaII triplet absorption lines show that, in the metal rich central region, the continuum is dominated by a population of red supergiants. The gaseous and stellar kinematics along three slit position angles, suggest the existence of a hierarchy of disks within disks, whose dynamics are decoupled at the two ILRs, that we find at 180 pc and at 1100 pc. This is supported by the structure seen in the high resolution HST images. The nucleus is spatially resolved within a radius of 1.5 arcsec, just inside the innermost ILR. Outside the iILR, the stellar CaT velocity profile is resolved into two components, associated with the bar and the disk. Several results indicate that this is a dynamically old system. It is thus possible that a nuclear bar has existed in NGC 6951 that drove the gas towards the nucleus, as in the bars within bars scenario, but that this bar has already dissolved by the gas accumulated within the circumnuclear region. We discuss the possibility that the kinematical component inside the iILR could be due to a nuclear outflow produced by the combined effects of SN and SN remnants, or to a nuclear disk, as in the disk within disk scenario that we propose for the fueling of the AGN in NGC 6951.Comment: 14 pages, 16 figures. Accepted for publication in Astronomy and Astrophysics. High resolution images in http://www.iaa.es/~eperez/research/degas.htm

ANÁLISIS DEL DESEMPLEO, LA MIGRACIÓN Y LA POBREZA EN MÉXICO

La mayoría de los movimientos poblacionales en todas las regiones geográficas del mundo, obedecen principalmente a motivaciones vinculadas con la búsqueda de mejores condiciones de vida. No obstante, en casi todos los casos el costo social de lograr que los hogares reciban lo necesario para sobrevivir es la ruptura familiar y la seguridad personal.Los graves problemas que están enfrentando las economías subdesarrolladas con bajo o nulo crecimiento económico, altas tasas de desempleo, elevado índice de migración y millones de habitantes en pobreza extrema. El objetivo del presente trabajo fue analizar el desempleo, la migración y la pobreza en México. El desempleo es uno de los problemas de la economía mexicana (según INEGI de 5.5%), le sigue la migración y la pobreza extrema. Debido al incremento del desempleo y los bajos salarios que tiene el país estimulan a las personas a emigrar. Aunado a lo anterior, en Estados Unidos de América la tasa de desempleo de los migrantes mexicanos se elevó de 8.0% a 12.0% (2009) aproximadamente, provocando una fuerte disminución en las remesas, lo que trae como consecuencia una baja en los ingresos de las familias que viven de dichas transferencias ocasionando que se agudice la pobreza en el país

Taller: Socrative y JClic herramientas para dar los primeros pasos en geometría analítica y sucesiones

El presente taller va dirigido a docentes de primaria que deseen innovar en sus prácticas educativas mediante la aplicación de programas computacionales. Se desarrollará una unidad didáctica para enseñar geometría analítica y sucesiones en primaria, utilizando una metodología constructivista, basada en la resolución de problemas, según lo indicado en los programas de matemática, del Ministerio de Educación Pública (MEP) y con la utilización de las herramientas computacionales gratuitas JClic y Socrative

ACTIVIDADES PARA CONTRIBUIR A LA COMPRENSIÓN DE PROBLEMAS ARITMÉTICOS EN LA FORMACIÓN INICIAL DE MAESTROS PRIMARIOS

Primary Education today requires a professional prepared in the political, psychological, pedagogical and didactic aspects, and with mastery of the content. This is to develop a flexible and innovative educational work that links the general objectives in the formation of children, adolescents and young people, with the singularities of each one, including the particularities of the educational institution and its environment. Continuous improvement imposes on the University the task of preparing young people for life. The development of arithmetic problem solving skills should be the focus of special attention, because of its importance from the practical point of view. Solving arithmetic problems has always been one of the main pillars of learning mathematics, which implies, among other things, knowing how to integrate objects, definitions and mathematical representations in a coherent manner and knowing how to use these configurations to find the correct answers to the given problem. With this objective, in this research, it is offered a set of activities to favor the resolution of arithmetic problems in students of the Bachelor's Degree in Primary Education of the Faculty of Educational Sciences, from the training in the use of heuristic procedures, specifying the work with the heuristic auxiliary means.La Educación Primaria requiere hoy de un profesional preparado en lo político, psicológico, pedagógico y didáctico, y con dominio del contenido que imparte. Esto es para desarrollar una labor educativa flexible e innovadora que vincule los objetivos generales en la formación de niños, adolescentes y jóvenes, con las singularidades de cada uno, incluyendo las particularidades de la institución educativa y de su entorno. El perfeccionamiento continuo, impone a la Universidad la tarea de preparar a los jóvenes para la vida. El desarrollo de habilidades para resolver problemas aritméticos ha de estar en el foco de especial atención, por la importancia que reviste desde el punto de vista práctico. La resolución de problemas aritméticos siempre ha sido uno de los grandes pilares del aprendizaje de las matemáticas, esto implica, entre otras cosas, saber integrar de manera coherente objetos, definiciones, representaciones matemáticas y saber usar esas configuraciones para encontrar respuestas correctas al problema dado. Con ese objetivo se ofrece, en esta investigación, un conjunto de actividades para favorecer la resolución de problemas aritméticos en los estudiantes de la Licenciatura en Educación Primaria de la Facultad Ciencias de la Educación, a partir del adiestramiento en el uso de procedimientos heurísticos, especificando el trabajo con los medios auxiliares heurísticos

Characterization of micromobility crashes in Spain (2016-2020)

Micromobility has a direct impact on the urban area, since it tries to make cities more liveable, o:ffering an alternative transport option that contributes to reduce air and noise pollution. Additionally, it promotes intennodality, promotes money savings, reduces parking space and helps to avoid road congestion in cities that have their own lanes for the use of micromobility vehicles such as bicycles, stand-up e-scooters (escooters) and other personal mobility vehicles (PMVs). In Spain, micromobility has significantly increased in recent years, through the increase in the supply and demand for bicycles and other PMVs, mainly e-scooters. There are many reasons that have motivated users to prioritize the bicycle and the other PMVs over other means of tra.nsport. In addition to the growing concern for health and the environment, the COVID-19 pandemic has also driven the growth in the use ofthe different PMVs in 2020. Accordmg to data from Global Public Transport Report, published by the mobility application Moovit, 31 % of Spanianis have used bicycles, scooters or e-scooters in 2020, increasing their use by 7% since 2019. However, in parallel and because of the increase in PMVs exposure, the number of crashes involving users of these vehicles has also increased in recent years. For this reason, among road safety researchers, interest and concern for the study of this kind of crashes have also increased The aim of this research is to characterize the crashes in Spain in which at least one PMV (bicycle, e-scooter or other PMV) is involved between the years 2016 and 2020

Hydralazine target: From blood vessels to the epigenome

Hydralazine was one of the first orally active antihypertensive drugs developed. Currently, it is used principally to treat pregnancy-associated hypertension. Hydralazine causes two types of side effects. The first type is an extension of the pharmacologic effect of the drug and includes headache, nausea, flushing, hypotension, palpitation, tachycardia, dizziness, and salt retention. The second type of side effects is caused by immunologic reactions, of which the drug-induced lupus-like syndrome is the most common, and provides clues to underscoring hydralazine's DNA demethylating property in connection with studies demonstrating the participation of DNA methylation disorders in immune diseases. Abnormalities in DNA methylation have long been associated with cancer. Despite the fact that malignant tumors show global DNA hypomethylation, regional hypermethylation as a means to silence tumor suppressor gene expression has attracted the greatest attention. Reversibility of methylation-induced gene silencing by pharmacologic means, which in turns leads to antitumor effects in experimental and clinical scenarios, has directed efforts toward developing clinically useful demethylating agents. Among these, the most widely used comprise the nucleosides 5-azacytidine and 2'deoxy-5-azacytidine; however, these agents, like current cytotoxic chemotherapy, causes myelosuppression among other side effects that could limit exploitation of their demethylating properties. Among non-nucleoside DNA demethylating drugs currently under development, the oral drug hydralazine possess the ability to reactivate tumor suppressor gene expression, which is silenced by promoter hypermethylation in vitro and in vivo. Decades of extensive hydralazine use for hypertensive disorders that demonstrated hydralazine's clinical safety and tolerability supported its testing in a phase I trial in patients with cancer, confirming its DNA demethylating activity. Hydralazine is currently being evaluated, along with histone deacetylase inhibitors either alone or as adjuncts to chemotherapy and radiation, for hematologic and solid tumors in phase II studies

Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study

BACKGROUND: The development of cancer has been associated with epigenetic alterations such as aberrant histone deacetylase (HDAC) activity. It was recently reported that valproic acid is an effective inhibitor of histone deacetylases and as such induces tumor cell differentiation, apoptosis, or growth arrest. METHODS: Twelve newly diagnosed patients with cervical cancer were treated with magnesium valproate after a baseline tumor biopsy and blood sampling at the following dose levels (four patients each): 20 mg/kg; 30 mg/kg, or 40 mg/kg for 5 days via oral route. At day 6, tumor and blood sampling were repeated and the study protocol ended. Tumor acetylation of H3 and H4 histones and HDAC activity were evaluated by Western blot and colorimetric HDAC assay respectively. Blood levels of valproic acid were determined at day 6 once the steady-state was reached. Toxicity of treatment was evaluated at the end of study period. RESULTS: All patients completed the study medication. Mean daily dose for all patients was 1,890 mg. Corresponding means for the doses 20-, 30-, and 40-mg/kg were 1245, 2000, and 2425 mg, respectively. Depressed level of consciousness grade 2 was registered in nine patients. Ten patients were evaluated for H3 and H4 acetylation and HDAC activity. After treatment, we observed hyperacetylation of H3 and H4 in the tumors of nine and seven patients, respectively, whereas six patients demonstrated hyperacetylation of both histones. Serum levels of valproic acid ranged from 73.6–170.49 μg/mL. Tumor deacetylase activity decreased in eight patients (80%), whereas two had either no change or a mild increase. There was a statistically significant difference between pre and post-treatment values of HDAC activity (mean, 0.36 vs. 0.21, two-tailed t test p < 0.0264). There was no correlation between H3 and H4 tumor hyperacetylation with serum levels of valproic acid. CONCLUSION: Magnesium valproate at a dose between 20 and 40 mg/kg inhibits deacetylase activity and hyperacetylates histones in tumor tissues

ANÃLISIS DEL DESEMPLEO, LA MIGRACIÓN Y LA POBREZA EN MÉXICO

Undeveloped economies are dealing with very big issues such as low or null economic growth, higher rates of unemployment, high index of migration and millions of people living in extreme poverty. Therefore, the present investigation aims to analyze unemployment, migration and poverty in Mexico; since unemployment in Mexico has a rate of 5.5% according to INEGI, followed by migration and extreme poverty. One of the most important effects from the previous matters is that they have stimulated people to migrate. Because of the unemployment increase and the low wages in the country it has been stimulated the population to migrate. In addition, in the USA, the unemployment rate of Mexican migrants has raised from 8.0 to 12.0% (2009) approximately, inducing a strong decrease in remittances, which brings as a consequence a diminish in families revenue that depend on such remittances, causing an intensification in the country's poverty.Unemployment, migration, poverty, remittances and income., Agribusiness,